Impact of saturable distribution in compartmental PK models: dynamics and practical use

We explore the impact of saturable distribution over the central and the peripheral compartment in pharmacokinetic models, whilst assuming that back flow into the central compartiment is linear. Using simulations and analytical methods we demonstrate characteristic tell-tale differences in plasma co...

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Detalles Bibliográficos
Autores principales: Peletier, Lambertus A., de Winter, Willem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306145/
https://www.ncbi.nlm.nih.gov/pubmed/28050672
http://dx.doi.org/10.1007/s10928-016-9500-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306145/
https://www.ncbi.nlm.nih.gov/pubmed/28050672
http://dx.doi.org/10.1007/s10928-016-9500-2

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