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Impact of saturable distribution in compartmental PK models: dynamics and practical use
We explore the impact of saturable distribution over the central and the peripheral compartment in pharmacokinetic models, whilst assuming that back flow into the central compartiment is linear. Using simulations and analytical methods we demonstrate characteristic tell-tale differences in plasma co...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306145/ https://www.ncbi.nlm.nih.gov/pubmed/28050672 http://dx.doi.org/10.1007/s10928-016-9500-2 |