Impact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel

BACKGROUND AND OBJECTIVES: Resistance to the antiplatelet treatment with clopidogrel has both genetic and non-genetic causes. Polymorphic variants of cytochrome P450 3A4 isoenzyme involved in the bioactivation of clopidogrel might have an influence on responsiveness to the drug. The aim of this stud...

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Detalles Bibliográficos
Autores principales: Danielak, Dorota, Karaźniewicz-Łada, Marta, Wiśniewska, Karolina, Bergus, Piotr, Burchardt, Paweł, Komosa, Anna, Główka, Franciszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306247/
https://www.ncbi.nlm.nih.gov/pubmed/26891871
http://dx.doi.org/10.1007/s13318-016-0324-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306247/
https://www.ncbi.nlm.nih.gov/pubmed/26891871
http://dx.doi.org/10.1007/s13318-016-0324-7

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