Cargando…

A phase III, open label, randomized multicenter controlled trial of oral versus intravenous treosulfan in heavily pretreated recurrent ovarian cancer: a study of the North-Eastern German Society of Gynecological Oncology (NOGGO)

OBJECTIVE: In recurrent ovarian cancer (ROC), there is a high demand on effective therapies with a mild toxicity profile. Treosulfan is an alkylating agent approved as oral (p.o.) and intravenous (i.v.) formulation for the treatment of recurrent ovarian cancer. Data on safety and efficacy for either...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sehouli, Jalid, Tomè, Oliver, Dimitrova, Desislava, Camara, Oumar, Runnebaum, Ingo Bernhard, Tessen, Hans Werner, Rautenberg, Beate, Chekerov, Radoslav, Muallem, Mustafa Zelal, Lux, Michael Patrick, Trarbach, Tanja, Gitsch, Gerald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Original Article – Clinical Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306340/ https://www.ncbi.nlm.nih.gov/pubmed/27896440 http://dx.doi.org/10.1007/s00432-016-2307-0

Ejemplares similares

Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group
por: Trillsch, Fabian, et al.
Publicado: (2021)

Results of a German wide survey towards current surgical approach in early stage cervical cancer NOGGO MONITOR 11
por: Armbrust, Robert, et al.
Publicado: (2021)

Can a morphological description of the peritoneal carcinomatosis in advanced ovarian cancer add prognostic information? Analysis of 1686 patients of the tumor bank ovarian cancer
por: Nasser, Sara, et al.
Publicado: (2022)

Influence of migrant background on patient preference and expectations in breast and gynecological malignancies (NOGGO-expression V study): results of a prospective multicentre study in 606 patients in Germany
por: Dimitrova, D., et al.
Publicado: (2021)

Nerve-Sparing Systematic Lymph Node Dissection in Gynaecological Oncology: An Innovative Neuro-Anatomical and Surgical Protocol for Enhanced Functional Outcomes
por: Muallem, Mustafa Zelal, et al.
Publicado: (2020)

Interkulturelle Kompetenzen im Gesundheitswesen durch Fort- und Weiterbildungen fördern
por: Dimitrova, Desislava, et al.
Publicado: (2023)

Sentinel Lymph Node Staging with Indocyanine Green for Patients with Cervical Cancer: The Safety and Feasibility of Open Approach Using SPY-PHI Technique
por: Muallem, Mustafa Zelal, et al.
Publicado: (2021)

A Promising Approach for Primary Cytoreductive Surgery for Advanced Ovarian Cancer: Survival Outcomes and Step-by-Step Description of Total Retroperitoneal en-Bloc Resection of Multivisceral-Peritoneal Packet (TROMP)
por: Muallem, Mustafa Zelal, et al.
Publicado: (2022)

Current Treatment Practices and Prognostic Factors in Early-Stage Ovarian Cancer—An Analysis of the NOGGO/JAGO
por: Heublein, Sabine, et al.
Publicado: (2023)

Bevacizumab Combined with Platinum–Taxane Chemotherapy as First-Line Treatment for Advanced Ovarian Cancer: Results of the NOGGO Non-Interventional Study (OTILIA) in 824 Patients
por: Sehouli, Jalid, et al.
Publicado: (2021)

A Concise Paradigm on Radical Hysterectomy: The Comprehensive Anatomy of Parametrium, Paracolpium and the Pelvic Autonomic Nerve System and Its Surgical Implication
por: Muallem, Mustafa Zelal, et al.
Publicado: (2020)

Reconstructive Surgery versus Primary Closure following Vulvar Cancer Excision: A Wide Single-Center Experience
por: Muallem, Mustafa Zelal, et al.
Publicado: (2022)

Knowledge and understanding risk factors and preventive measures for osteoporosis in women: results of a survey in 502 women with and without a migration background
por: Taghvaei, Reza, et al.
Publicado: (2022)

Real-World Evidence: How Long Do Our Patients Fast?—Results from a Prospective JAGO-NOGGO-Multicenter Analysis on Perioperative Fasting in 924 Patients with Malignant and Benign Gynecological Diseases
por: Beck, Maximilian Heinz, et al.
Publicado: (2023)

Checkpoint-inhibition in ovarian cancer: rising star or just a dream?
por: Pietzner, Klaus, et al.
Publicado: (2018)

Preference of elderly patients’ to oral or intravenous chemotherapy in heavily pre-treated recurrent ovarian cancer: final results of a prospective multicenter trial
por: Chekerov, Radoslav, et al.
Publicado: (2017)

A prospective multicenter study of treosulfan in elderly patients with recurrent ovarian cancer: results of a planned safety analysis
por: Mahner, Sven, et al.
Publicado: (2012)

Current trends in diagnostic and therapeutic management of the axilla in breast cancer patients receiving neoadjuvant therapy: results of the German-wide NOGGO MONITOR 24 survey
por: Banys-Paluchowski, Maggie, et al.
Publicado: (2022)

Preoperative HE4 and ROMA values do not improve the CA125 diagnostic value for borderline tumors of the ovary (BOT) – a study of the TOC Consortium
por: Braicu, Elena Ioana, et al.
Publicado: (2014)

Pelvic floor hypertension: possible factors for pelvic floor tenderness in endometriosis patients—a pilot study
por: Muallem, Jumana, et al.
Publicado: (2023)

DNA alkylation and interstrand cross-linking by treosulfan
por: Hartley, J A, et al.
Publicado: (1999)

Treosulfan-based conditioning for inborn errors of immunity
por: Slatter, Mary A., et al.
Publicado: (2021)

A New Anatomic and Staging-Oriented Classification of Radical Hysterectomy
por: Muallem, Mustafa Zelal
Publicado: (2021)

Treosulfan induces distinctive gonadal toxicity compared with busulfan
por: Levi, Mattan, et al.
Publicado: (2018)

In Vitro Study of the Enzymatic and Nonenzymatic Conjugation of Treosulfan with Glutathione
por: Romański, Michał, et al.
Publicado: (2019)

Treosulfan-Based Conditioning Regimen for Second Allograft in Patients with Myelofibrosis
por: Atagunduz, Isik Kaygusuz, et al.
Publicado: (2020)

Development of the NOGGO GIS v1 Assay, a Comprehensive Hybrid-Capture-Based NGS Assay for Therapeutic Stratification of Homologous Repair Deficiency Driven Tumors and Clinical Validation
por: Willing, Eva-Maria, et al.
Publicado: (2023)

Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer
por: Kulbe, Hagen, et al.
Publicado: (2019)

Key regulator of cellular metabolism, estrogen-related receptor α, a new therapeutic target in endocrine-related gynecological tumor
por: Liu, GuiFen, et al.
Publicado: (2018)

Preoperative quality of life as prediction for severe postoperative complications in gynecological cancer surgery: results of a prospective study
por: Sehouli, Jalid, et al.
Publicado: (2020)

Trabectedin plus pegylated liposomal doxorubicin (PLD) for patients with platinum-sensitive recurrent ovarian cancer: a prospective, observational, multicenter study
por: Runnebaum, Ingo B., et al.
Publicado: (2018)

Impact of health-related quality of life (HRQoL) on short-term mortality in patients with recurrent ovarian, fallopian or peritoneal carcinoma (the NOGGO-AGO QoL Prognosis-Score-Study): results of a meta-analysis in 2209 patients
por: Armbrust, R., et al.
Publicado: (2021)

Correction to: Preoperative quality of life as prediction for severe postoperative complications in gynecological cancer surgery: results of a prospective study
por: Sehouli, Jalid, et al.
Publicado: (2021)

Efficacy and Safety of High-Dose Chemotherapy with Treosulfan and Melphalan in Multiple Myeloma
por: Gillich, Cédric, et al.
Publicado: (2023)

Patient involvement in research within the Gynecological Cancer InterGroup: A call to action for a systematic approach: Results from a survey
por: Nohová, Ivana, et al.
Publicado: (2023)

Side Effects from Cancer Therapies and Perspective of 1044 Long-Term Ovarian Cancer Survivors—Results of Expression VI–Carolin Meets HANNA–Holistic Analysis of Long-Term Survival with Ovarian Cancer: The International NOGGO, ENGOT, and GCIG Survey
por: Woopen, Hannah, et al.
Publicado: (2023)

Nerve Sparing Radical Hysterectomy: Short-Term Oncologic, Surgical, and Functional Outcomes
por: Muallem, Mustafa Zelal, et al.
Publicado: (2020)

Real-World Experience with Pembrolizumab Treatment in Patients with Heavily Treated Recurrent Gynecologic Malignancies
por: Choi, Min Chul, et al.
Publicado: (2020)

Stable expansion of high‐grade serous ovarian cancer organoids requires a low‐Wnt environment
por: Hoffmann, Karen, et al.
Publicado: (2020)

Cisplatin, gemcitabine, and treosulfan in relapsed stage IV cutaneous malignant melanoma patients
por: Atzpodien, J, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_psrdr4sedh344ejp4g9dobi24b