CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene

Wild-derived mice have contributed to experimental mouse genetics by virtue of their genetic diversity, which may help increase the chance of identifying novel modifier genes responsible for specific phenotypes and diseases. However, gene targeting using wild-derived mice has been unsuccessful becau...

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Detalles Bibliográficos
Autores principales: Hirose, Michiko, Hasegawa, Ayumi, Mochida, Keiji, Matoba, Shogo, Hatanaka, Yuki, Inoue, Kimiko, Goto, Tatsuhiko, Kaneda, Hideki, Yamada, Ikuko, Furuse, Tamio, Abe, Kuniya, Uenoyama, Yoshihisa, Tsukamura, Hiroko, Wakana, Shigeharu, Honda, Arata, Ogura, Atsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307340/
https://www.ncbi.nlm.nih.gov/pubmed/28195201
http://dx.doi.org/10.1038/srep42476