Smoothened is a poor prognosis factor and a potential therapeutic target in glioma

Malignant gliomas are associated with a high mortality rate. Thus, there is an urgent need for the development of novel targeted therapeutics. Aberrant Hedgehog signaling has been directly linked to glioma. GDC-0449 is a novel small molecule inhibitor of Hedgehog signaling that blocks the activity o...

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Detalles Bibliográficos
Autores principales: Tu, Yiming, Niu, Mingshan, Xie, Peng, Yue, Chenglong, Liu, Ning, Qi, Zhenglei, Gao, Shangfeng, Liu, Hongmei, Shi, Qiong, Yu, Rutong, Liu, Xuejiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307388/
https://www.ncbi.nlm.nih.gov/pubmed/28195165
http://dx.doi.org/10.1038/srep42630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307388/
https://www.ncbi.nlm.nih.gov/pubmed/28195165
http://dx.doi.org/10.1038/srep42630

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