Cargando…

A Novel Toxin from Haplopelma lividum Selectively Inhibits the Na(V)1.8 Channel and Possesses Potent Analgesic Efficacy

Spider venoms are a complex mixture of peptides with a large number of neurotoxins targeting ion channels. Although thousands of peptide toxins have been identified from venoms of numerous species of spiders, many unknown species urgently need to be investigated. In this study, a novel sodium channe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Ping, Huang, Honggang, Wang, Gan, Yang, Shilong, Lu, Qiuming, Liu, Jingze, Lai, Ren, Rong, Mingqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308240/ https://www.ncbi.nlm.nih.gov/pubmed/28035974 http://dx.doi.org/10.3390/toxins9010007

Ejemplares similares

Haplopelma hainanum venom induces inflammatory skin lesions
por: Deng, Zhili, et al.
Publicado: (2020)

Locomotor mechanism of Haplopelma hainanum based on energy conservation analysis
por: Hao, Xin, et al.
Publicado: (2020)

Discovery of a Novel Na(v)1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy
por: Zhang, Yunxiao, et al.
Publicado: (2018)

Isolation of Janthinobacterium lividum from early onset neonatal sepsis patients in Malaysia
por: Shinkafi, Sa'adatu Haruna, et al.
Publicado: (2019)

Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain
por: Zeng, Xiongzhi, et al.
Publicado: (2018)

Draft genome sequence of Janthinobacterium lividum strain MTR reveals its mechanism of capnophilic behavior
por: Valdes, Natalia, et al.
Publicado: (2015)

Janthinobacterium lividum as An Emerging Pathogenic Bacterium Affecting Rainbow Trout (Oncorhynchus mykiss) Fisheries in Korea
por: Oh, Woo Taek, et al.
Publicado: (2019)

Molecular signatures of Janthinobacterium lividum from Trinidad support high potential for crude oil metabolism
por: Ramdass, Amanda C., et al.
Publicado: (2021)

First Complete Genome Sequences of Janthinobacterium lividum EIF1 and EIF2 and Their Comparative Genome Analysis
por: Friedrich, Ines, et al.
Publicado: (2020)

Analgesic Effect of the Lysine-Containing Short Peptide Is Due to Modulation of the Na(V)1.8 Channel Activation Gating System
por: Kalinina, Arina D., et al.
Publicado: (2023)

Sargassopenillines A–G, 6,6-Spiroketals from the Alga-Derived Fungi Penicillium thomii and Penicillium lividum
por: Zhuravleva, Olesya I., et al.
Publicado: (2014)

Investigating the potential use of an Antarctic variant of Janthinobacterium lividum for tackling antimicrobial resistance in a One Health approach
por: Baricz, Andreea, et al.
Publicado: (2018)

Predominant Microbial Colonizers in the Root Endosphere and Rhizosphere of Turfgrass Systems: Pseudomonas veronii, Janthinobacterium lividum, and Pseudogymnoascus spp.
por: Xia, Qing, et al.
Publicado: (2021)

Draft Genome Sequence of Janthinobacterium lividum ID1246, Isolated from a Rainbow Trout Hatchery Biofilm
por: Testerman, Todd, et al.
Publicado: (2021)

Differential Interactions of Na(+) Channel Toxins with T-type Ca(2+) Channels
por: Sun, Hui, et al.
Publicado: (2008)

Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
Publicado: (1984)

Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin
por: Duarte, Yorley, et al.
Publicado: (2020)

The Role of Toxins in the Pursuit for Novel Analgesics
por: Maatuf, Yossi, et al.
Publicado: (2019)

Bioinformatic characterizations and prediction of K(+ )and Na(+ )ion channels effector toxins
por: Soli, Rima, et al.
Publicado: (2009)

Voltage-Gated K(+)/Na(+) Channels and Scorpion Venom Toxins in Cancer
por: Díaz-García, Alexis, et al.
Publicado: (2020)

Aqueous Methanol Extracts of Cochlospermum tinctorium (A. Rich) Possess Analgesic and Anti-inflammatory Activities
por: Ahmed, TS, et al.
Publicado: (2011)

Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel
por: Hakim, Md Abdul, et al.
Publicado: (2015)

Draft Genome Sequences of Two Janthinobacterium lividum Strains, Isolated from Pristine Groundwater Collected from the Oak Ridge Field Research Center
por: Wu, Xiaoqin, et al.
Publicado: (2017)

Strategies for high-altitude adaptation revealed from high-quality draft genome of non-violacein producing Janthinobacterium lividum ERGS5:01
por: Kumar, Rakshak, et al.
Publicado: (2018)

Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus
Publicado: (1989)

The Outer Vestibule of the Na(+) Channel–Toxin Receptor and Modulator of Permeation as Well as Gating
por: Cervenka, René, et al.
Publicado: (2010)

Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K(+) and Na(+) Channels
por: Van Theemsche, Kenny M., et al.
Publicado: (2020)

From structure to function: unveiling the structure of the Na(v) channel–toxin complex
por: Zhou, Zhuan, et al.
Publicado: (2019)

Analgesic Effects of Botulinum Toxin in Children with CP
por: Sandahl Michelsen, Josephine, et al.
Publicado: (2018)

A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds
por: Rong, Mingqiang, et al.
Publicado: (2016)

The Analgesic Activity of Bestatin as a Potent APN Inhibitor
por: Jia, Mei-Rong, et al.
Publicado: (2010)

Long-Term Blockade of Nociceptive Na(v)1.7 Channels Is Analgesic in Rat Models of Knee Arthritis
por: Reid, Allison R., et al.
Publicado: (2022)

Deoxyarbutin Possesses a Potent Skin-Lightening Capacity with No Discernible Cytotoxicity against Melanosomes
por: Miao, Fang, et al.
Publicado: (2016)

A Combinational Strategy upon RNA Sequencing and Peptidomics Unravels a Set of Novel Toxin Peptides in Scorpion Mesobuthus martensii
por: Luan, Ning, et al.
Publicado: (2016)

Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects
por: Verkest, Clément, et al.
Publicado: (2022)

Chemical Synthesis, Proper Folding, Na(v) Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1
por: Nicolas, Sébastien, et al.
Publicado: (2019)

Could Mycolactone Inspire New Potent Analgesics? Perspectives and Pitfalls
por: Reynaert, Marie-Line, et al.
Publicado: (2019)

Buprenorphine in rats: potent analgesic or trigger for fatal side effects?
por: Reifenrath, Janin, et al.
Publicado: (2022)

Phosphonium Ionic Liquid-Infused Poly(vinyl chloride) Surfaces Possessing Potent Antifouling Properties
por: Wylie, Matthew P., et al.
Publicado: (2020)

Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties
por: Corman, Hannah N., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_00lhpf2105ip2dtui4stph1914