Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication

The AB-type protein toxin from Pasteurella multocida (PMT) contains a functionally important disulfide bond within its catalytic domain, which must be cleaved in the host cell cytosol to render the catalytic domain of PMT into its active conformation. Here, we found that the reductive potential of t...

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Detalles Bibliográficos
Autores principales: Carle, Stefan, Brink, Thorsten, Orth, Joachim H. C., Aktories, Klaus, Barth, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308264/
https://www.ncbi.nlm.nih.gov/pubmed/28098782
http://dx.doi.org/10.3390/toxins9010032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308264/
https://www.ncbi.nlm.nih.gov/pubmed/28098782
http://dx.doi.org/10.3390/toxins9010032

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