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Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication
The AB-type protein toxin from Pasteurella multocida (PMT) contains a functionally important disulfide bond within its catalytic domain, which must be cleaved in the host cell cytosol to render the catalytic domain of PMT into its active conformation. Here, we found that the reductive potential of t...
Autores principales: | Carle, Stefan, Brink, Thorsten, Orth, Joachim H. C., Aktories, Klaus, Barth, Holger |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308264/ https://www.ncbi.nlm.nih.gov/pubmed/28098782 http://dx.doi.org/10.3390/toxins9010032 |
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