Hypoxia-responsive ionizable liposome delivery siRNA for glioma therapy

Here, we report the hypoxia-responsive ionizable liposomes to deliver small interference RNA (siRNA) anticancer drugs, which can selectively enhance cellular uptake of the siRNA under hypoxic and low-pH conditions to cure glioma. For this purpose, malate dehydrogenase lipid molecules were synthesize...

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Detalles Bibliográficos
Autores principales: Liu, Hong-Mei, Zhang, Ya-Fei, Xie, Yan-Dong, Cai, Yi-Fan, Li, Bai-Yang, Li, Wen, Zeng, Ling-Yu, Li, Yu-Ling, Yu, Ru-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308568/
https://www.ncbi.nlm.nih.gov/pubmed/28223799
http://dx.doi.org/10.2147/IJN.S125286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308568/
https://www.ncbi.nlm.nih.gov/pubmed/28223799
http://dx.doi.org/10.2147/IJN.S125286

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