Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis

One of the earliest requirements for the formation of a solid tumor is the establishment of an adequate blood supply. Clear cell renal cell carcinomas (ccRCC) are highly vascularized tumors in which the earliest genetic event is most commonly the biallelic inactivation of the VHL tumor suppressor ge...

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Detalles Bibliográficos
Autores principales: Schönenberger, Désirée, Rajski, Michal, Harlander, Sabine, Frew, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308630/
https://www.ncbi.nlm.nih.gov/pubmed/27528422
http://dx.doi.org/10.18632/oncotarget.11275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308630/
https://www.ncbi.nlm.nih.gov/pubmed/27528422
http://dx.doi.org/10.18632/oncotarget.11275

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