PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation

Despite therapeutic advancement, multiple myeloma (MM) remains incurable with drug resistance being one of the main challenges in the clinic. Myeloma cells possess high protein secretory load, leading to increased intracellular endoplasmic reticulum (ER) stress. Hence, they are vulnerable to further...

Descripción completa

Detalles Bibliográficos
Autores principales: Teoh, Phaik Ju, Bi, Chonglei, Sintosebastian, Chirackal, Tay, Liang Seah, Fonseca, Rafael, Chng, Wee Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308692/
https://www.ncbi.nlm.nih.gov/pubmed/27533450
http://dx.doi.org/10.18632/oncotarget.11241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308692/
https://www.ncbi.nlm.nih.gov/pubmed/27533450
http://dx.doi.org/10.18632/oncotarget.11241

Ejemplares similares