Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples

The development of breast and ovarian cancer is strongly connected to the inactivation of the BRCA1 and BRCA2 genes by different germline and somatic alterations, and their diagnosis has great significance in targeted tumor therapy, since recently approved PARP inhibitors show high efficiency in the...

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Detalles Bibliográficos
Autores principales: Enyedi, Márton Zsolt, Jaksa, Gábor, Pintér, Lajos, Sükösd, Farkas, Gyuris, Zoltán, Hajdu, Adrienn, Határvölgyi, Erika, Priskin, Katalin, Haracska, Lajos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308695/
https://www.ncbi.nlm.nih.gov/pubmed/27533253
http://dx.doi.org/10.18632/oncotarget.11259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308695/
https://www.ncbi.nlm.nih.gov/pubmed/27533253
http://dx.doi.org/10.18632/oncotarget.11259

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