De-novo NAD(+) synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells

Tryptophan metabolism is essential in diverse kinds of tumors via regulating tumor immunology. However, the direct role of tryptophan metabolism and its signaling pathway in cancer cells remain largely elusive. Here, we establish a mechanistic link from L-type amino acid transporter 1 (LAT1) mediate...

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Detalles Bibliográficos
Autores principales: Liu, Huiying, Xing, Rong, Cheng, Xuefang, Li, Qingran, Liu, Fang, Ye, Hui, Zhao, Min, Wang, Hong, Wang, Guangji, Hao, Haiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308742/
https://www.ncbi.nlm.nih.gov/pubmed/27566573
http://dx.doi.org/10.18632/oncotarget.11526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308742/
https://www.ncbi.nlm.nih.gov/pubmed/27566573
http://dx.doi.org/10.18632/oncotarget.11526

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