The novel compound STK405759 is a microtubule-targeting agent with potent and selective cytotoxicity against multiple myeloma in vitro and in vivo

Despite advances in treatment, multiple myeloma (MM) remains incurable. Here we propose the use of STK405759, a novel microtubule targeting agent (MTA) and member of the furan metotica family for MM therapy. STK405759 inhibited tubulin polymerization in a cell-free system and in myeloma cells. This...

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Detalles Bibliográficos
Autores principales: Rozic, Gabriela, Paukov, Lena, Jakubikova, Jana, Ben-Shushan, Dikla, Duek, Adrian, Leiba, Adi, Avigdor, Abraham, Nagler, Arnon, Leiba, Merav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308747/
https://www.ncbi.nlm.nih.gov/pubmed/27613836
http://dx.doi.org/10.18632/oncotarget.11539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308747/
https://www.ncbi.nlm.nih.gov/pubmed/27613836
http://dx.doi.org/10.18632/oncotarget.11539

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