Cargando…
Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein
Receptor Tyrosine Kinase (RTK) signaling plays a major role in tumorigenesis and normal development. Sprouty2 (Spry2) attenuates RTK signaling and inhibits processes such as angiogenesis, cell proliferation, migration and survival, which are all upregulated in tumors. Indeed in cancers of the liver,...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308774/ https://www.ncbi.nlm.nih.gov/pubmed/28196140 http://dx.doi.org/10.1371/journal.pone.0171616 |