A conformational switch regulates the ubiquitin ligase HUWE1

The human ubiquitin ligase HUWE1 has key roles in tumorigenesis, yet it is unkown how its activity is regulated. We present the crystal structure of a C-terminal part of HUWE1, including the catalytic domain, and reveal an asymmetric auto-inhibited dimer. We show that HUWE1 dimerizes in solution and...

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Detalles Bibliográficos
Autores principales: Sander, Bodo, Xu, Wenshan, Eilers, Martin, Popov, Nikita, Lorenz, Sonja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308896/
https://www.ncbi.nlm.nih.gov/pubmed/28193319
http://dx.doi.org/10.7554/eLife.21036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308896/
https://www.ncbi.nlm.nih.gov/pubmed/28193319
http://dx.doi.org/10.7554/eLife.21036

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