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Nanoparticle-linked antagonist for leptin signaling inhibition in breast cancer

AIM: To develop a leptin peptide receptor antagonist linked to nanoparticles and determine its effect on viability of breast cancer cells. METHODS: The leptin antagonist, LPrA2, was coupled via EDAC [1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide] to iron oxide nanoparticles (IONP-LPrA2) to increase...

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Detalles Bibliográficos
Autores principales: Harmon, Tia, Harbuzariu, Adriana, Lanier, Viola, Lipsey, Crystal C, Kirlin, Ward, Yang, Lily, Gonzalez-Perez, Ruben R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309714/
https://www.ncbi.nlm.nih.gov/pubmed/28246585
http://dx.doi.org/10.5306/wjco.v8.i1.54