Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Effective treatment for managing myocardial infarction (MI) remains an urgent, unmet clinical need. Formyl peptide receptors (FPR) regulate inflammation, a major contributing mechanism to cardiac injury following MI. Here we demonstrate that FPR1/FPR2-biased agonism may represent a novel therapeutic...

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Detalles Bibliográficos
Autores principales: Qin, Cheng Xue, May, Lauren T., Li, Renming, Cao, Nga, Rosli, Sarah, Deo, Minh, Alexander, Amy E., Horlock, Duncan, Bourke, Jane E., Yang, Yuan H., Stewart, Alastair G., Kaye, David M., Du, Xiao-Jun, Sexton, Patrick M., Christopoulos, Arthur, Gao, Xiao-Ming, Ritchie, Rebecca H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309721/
https://www.ncbi.nlm.nih.gov/pubmed/28169296
http://dx.doi.org/10.1038/ncomms14232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309721/
https://www.ncbi.nlm.nih.gov/pubmed/28169296
http://dx.doi.org/10.1038/ncomms14232

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