Cargando…

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Effective treatment for managing myocardial infarction (MI) remains an urgent, unmet clinical need. Formyl peptide receptors (FPR) regulate inflammation, a major contributing mechanism to cardiac injury following MI. Here we demonstrate that FPR1/FPR2-biased agonism may represent a novel therapeutic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Cheng Xue, May, Lauren T., Li, Renming, Cao, Nga, Rosli, Sarah, Deo, Minh, Alexander, Amy E., Horlock, Duncan, Bourke, Jane E., Yang, Yuan H., Stewart, Alastair G., Kaye, David M., Du, Xiao-Jun, Sexton, Patrick M., Christopoulos, Arthur, Gao, Xiao-Ming, Ritchie, Rebecca H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309721/ https://www.ncbi.nlm.nih.gov/pubmed/28169296 http://dx.doi.org/10.1038/ncomms14232

Ejemplares similares

Correspondence: Reply to ‘Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury’
por: Qin, Cheng Xue, et al.
Publicado: (2018)

Correspondence: Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury
por: Cilibrizzi, Agostino
Publicado: (2018)

Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia–reperfusion injury?
por: Gavins, Felicity N.E.
Publicado: (2010)

Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac(2-26), Against Myocardial Infarction
por: Qin, Cheng Xue, et al.
Publicado: (2019)

cMet agonistic antibody attenuates apoptosis in ischaemia‐reperfusion–induced kidney injury
por: An, Jung Nam, et al.
Publicado: (2020)

Therapeutic Treatment Approaches Post–Myocardial Infarction: A Bias Toward Formyl Peptide Receptor Agonists
por: Zaman, Rysa, et al.
Publicado: (2019)

Complement in ischaemia–reperfusion injury and transplantation
por: Howard, Mark C., et al.
Publicado: (2021)

Necroptosis in Hepatosteatotic Ischaemia-Reperfusion Injury
por: Baidya, Raji, et al.
Publicado: (2020)

Correction to: Complement in ischaemia–reperfusion injury and transplantation
por: Howard, Mark C., et al.
Publicado: (2022)

Pretreatment with the ALDH2 agonist Alda-1 reduces intestinal injury induced by ischaemia and reperfusion in mice
por: Zhu, Qiankun, et al.
Publicado: (2017)

Augmenter of liver regeneration protects the kidney from ischaemia‐reperfusion injury in ferroptosis
por: Huang, Li‐li, et al.
Publicado: (2019)

Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure
por: Rueda, Patricia, et al.
Publicado: (2021)

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury
por: Martin, Jack L., et al.
Publicado: (2018)

Ischaemia-reperfusion injury in photodynamic therapy-treated mouse tumours
por: Korbelik, M, et al.
Publicado: (2003)

Which pathways trigger the role of complement in ischaemia/reperfusion injury?
por: Farrar, Conrad A., et al.
Publicado: (2012)

l‐Fucose prevention of renal ischaemia/reperfusion injury in Mice
por: Howard, Mark C., et al.
Publicado: (2019)

The cardioprotective potential of valsartan in myocardial ischaemia reperfusion injury
por: Hadi, Najah R., et al.
Publicado: (2015)

Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?
por: Rehling, Michael, et al.
Publicado: (2022)

The effects of ischaemic conditioning on lung ischaemia–reperfusion injury
por: Vlastos, Dimitrios, et al.
Publicado: (2022)

Oestrogen-mediated cardioprotection following ischaemia and reperfusion is mimicked by an oestrogen receptor (ER)α agonist and unaffected by an ERβ antagonist
por: Jeanes, Helen L, et al.
Publicado: (2008)

Hydroxychloroquine Protects against Cardiac Ischaemia/Reperfusion Injury In Vivo via Enhancement of ERK1/2 Phosphorylation
por: Bourke, Lauren, et al.
Publicado: (2015)

Formyl peptide receptor type 2 agonists to kick‐start resolution pharmacology
por: Perretti, Mauro, et al.
Publicado: (2020)

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation
por: Martin, Jack L., et al.
Publicado: (2019)

TRAF1 is a critical regulator of cerebral ischaemia–reperfusion injury and neuronal death
por: Lu, Yan-Yun, et al.
Publicado: (2013)

Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemia–reperfusion injury
por: Cao, Yirui, et al.
Publicado: (2023)

A new model for evaluation of thrombosis and ischaemia/reperfusion injury
por: Ravn, HB, et al.
Publicado: (1998)

Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats
por: Bartošíková, Lenka, et al.
Publicado: (2010)

Pathophysiology of early ischaemia reperfusion injury of the colon in aortic surgery
por: Khwaja, N, et al.
Publicado: (2004)

Systemic inflammation affects reperfusion following transient cerebral ischaemia
por: Burrows, F., et al.
Publicado: (2016)

Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury
por: Maneechote, Chayodom, et al.
Publicado: (2017)

Ischaemia reperfusion injury: mechanisms of progression to chronic graft dysfunction
por: Situmorang, Gerhard R., et al.
Publicado: (2018)

Klotho protein contributes to cardioprotection during ischaemia/reperfusion injury
por: Olejnik, Agnieszka, et al.
Publicado: (2020)

The Role of Extracellular DNA and Histones in Ischaemia-Reperfusion Injury of the Myocardium
por: Shah, Mohammed, et al.
Publicado: (2020)

Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury
por: Wang, Wenjun, et al.
Publicado: (2021)

How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury
por: Clarke, George, et al.
Publicado: (2021)

Extracellular histones are a target in myocardial ischaemia–reperfusion injury
por: Shah, Mohammed, et al.
Publicado: (2021)

Alterations in mitochondrial protein glycosylation in myocardial ischaemia reperfusion injury
por: Feng, Xinyu, et al.
Publicado: (2023)

Formyl Peptide Receptors from Immune and Vomeronasal System Exhibit Distinct Agonist Properties
por: Bufe, Bernd, et al.
Publicado: (2012)

Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis
por: Crocetti, Letizia, et al.
Publicado: (2021)

Aryl hydrocarbon receptor antagonism before reperfusion attenuates cerebral ischaemia/reperfusion injury in rats
por: Kwon, Jae-Im, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hsokphm1a98d9ojh5o29em620v