A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth

Breast cancer is a heterogeneous disease consisting of several subtypes. Among these subtypes, triple negative breast cancer is particularly difficult to treat. This is due to a lack of understanding of the mechanisms behind the disease, and consequently a lack of druggable targets. PAK4 plays criti...

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Detalles Bibliográficos
Autores principales: Rane, Chetan, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Crochiere, Marsha, Das-Gupta, Soumyasri, Minden, Audrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309789/
https://www.ncbi.nlm.nih.gov/pubmed/28198380
http://dx.doi.org/10.1038/srep42555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309789/
https://www.ncbi.nlm.nih.gov/pubmed/28198380
http://dx.doi.org/10.1038/srep42555

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