Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination

Antibody class-switch DNA recombination (CSR) is initiated by AID-introduced DSBs in the switch (S) regions targeted for recombination, as effected by Ku70/Ku86-mediated NHEJ. Ku-deficient B cells, however, undergo (reduced) CSR through an alternative(A)-NHEJ pathway, which introduces microhomologie...

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Detalles Bibliográficos
Autores principales: Zan, Hong, Tat, Connie, Qiu, Zhifang, Taylor, Julia R., Guerrero, Justin A., Shen, Tian, Casali, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309807/
https://www.ncbi.nlm.nih.gov/pubmed/28176781
http://dx.doi.org/10.1038/ncomms14244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309807/
https://www.ncbi.nlm.nih.gov/pubmed/28176781
http://dx.doi.org/10.1038/ncomms14244

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