Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions

The laboratory rat has been used as a surrogate to study human biology for more than a century. Here we present the first genome-scale network reconstruction of Rattus norvegicus metabolism, iRno, and a significantly improved reconstruction of human metabolism, iHsa. These curated models comprehensi...

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Detalles Bibliográficos
Autores principales: Blais, Edik M., Rawls, Kristopher D., Dougherty, Bonnie V., Li, Zhuo I., Kolling, Glynis L., Ye, Ping, Wallqvist, Anders, Papin, Jason A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309818/
https://www.ncbi.nlm.nih.gov/pubmed/28176778
http://dx.doi.org/10.1038/ncomms14250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309818/
https://www.ncbi.nlm.nih.gov/pubmed/28176778
http://dx.doi.org/10.1038/ncomms14250

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