Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation underlies many fundamental physiological processes. GPCR signalling is negatively regulated by β-arrestins, adaptor molecules that also activate different intracellular signalling pathways. Here we reveal that TRV12002...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Chun-Hua, Gong, Zheng, Liang, Zong-Lai, Liu, Zhi-Xin, Yang, Fan, Sun, Yu-Jing, Ma, Ming-Liang, Wang, Yi-Jing, Ji, Chao-Ran, Wang, Yu-Hong, Wang, Mei-Jie, Cui, Fu-Ai, Lin, Amy, Zheng, Wen-Shuai, He, Dong-Fang, Qu, Chang-xiu, Xiao, Peng, Liu, Chuan-Yong, Thomsen, Alex R. B., Joseph Cahill, Thomas, Kahsai, Alem W., Yi, Fan, Xiao, Kun-Hong, Xue, Tian, Zhou, Zhuan, Yu, Xiao, Sun, Jin-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309860/
https://www.ncbi.nlm.nih.gov/pubmed/28181498
http://dx.doi.org/10.1038/ncomms14335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309860/
https://www.ncbi.nlm.nih.gov/pubmed/28181498
http://dx.doi.org/10.1038/ncomms14335

Ejemplares similares