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PI3Kα isoform-dependent activation of RhoA regulates Wnt5a-induced osteosarcoma cell migration

BACKGROUND: We have reported that the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway mediated Wnt5a-induced osteosarcoma cell migration. However, the signaling pathways regulating Wnt5a/PI3K/Akt-mediated cell migration remains poorly defined in osteosarcoma cells. METHODS: We evaluated t...

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Detalles Bibliográficos
Autores principales:	Zhang, Ailiang, Yan, Ting, Wang, Kun, Huang, Zhihui, Liu, Jinbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310072/ https://www.ncbi.nlm.nih.gov/pubmed/28289332 http://dx.doi.org/10.1186/s12935-017-0396-8

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