Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8(+) T Cells

NOD mice, a model strain for human type 1 diabetes, express proinsulin (PI) in the thymus. However, insulin-reactive T cells escape negative selection, and subsequent activation of the CD8(+) T-cell clonotype G9C8, which recognizes insulin B15-23 via an αβ T-cell receptor (TCR) incorporating TRAV8-1...

Descripción completa

Detalles Bibliográficos
Autores principales: Pearson, James A., Thayer, Terri C., McLaren, James E., Ladell, Kristin, De Leenheer, Evy, Phillips, Amy, Davies, Joanne, Kakabadse, Dimitri, Miners, Kelly, Morgan, Peter, Wen, Li, Price, David A., Wong, F. Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310213/
https://www.ncbi.nlm.nih.gov/pubmed/26953160
http://dx.doi.org/10.2337/db15-1498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310213/
https://www.ncbi.nlm.nih.gov/pubmed/26953160
http://dx.doi.org/10.2337/db15-1498

Ejemplares similares