Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts, identifying a novel link between the two. Analy...

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Detalles Bibliográficos
Autores principales: Mellone, Massimiliano, Hanley, Christopher J., Thirdborough, Steve, Mellows, Toby, Garcia, Edwin, Woo, Jeongmin, Tod, Joanne, Frampton, Steve, Jenei, Veronika, Moutasim, Karwan A., Kabir, Tasnuva D., Brennan, Peter A, Venturi, Giulia, Ford, Kirsty, Herranz, Nicolas, Lim, Kue Peng, Clarke, James, Lambert, Daniel W., Prime, Stephen S., Underwood, Timothy J., Vijayanand, Pandurangan, Eliceiri, Kevin W., Woelk, Christopher, King, Emma V., Gil, Jesus, Ottensmeier, Christian H., Thomas, Gareth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310659/
https://www.ncbi.nlm.nih.gov/pubmed/27992856
http://dx.doi.org/10.18632/aging.101127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310659/
https://www.ncbi.nlm.nih.gov/pubmed/27992856
http://dx.doi.org/10.18632/aging.101127

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