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Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family

Viral capsids are structurally constrained by interactions among the amino acids (AAs) of their constituent proteins. Therefore, epistasis is expected to evolve among physically interacting sites and to influence the rates of substitution. To study the evolution of epistasis, we focused on the major...

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Detalles Bibliográficos
Autores principales: Redondo, Rodrigo A. F., de Vladar, Harold P., Włodarski, Tomasz, Bollback, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310724/
https://www.ncbi.nlm.nih.gov/pubmed/28053111
http://dx.doi.org/10.1098/rsif.2016.0139