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Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family
Viral capsids are structurally constrained by interactions among the amino acids (AAs) of their constituent proteins. Therefore, epistasis is expected to evolve among physically interacting sites and to influence the rates of substitution. To study the evolution of epistasis, we focused on the major...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310724/ https://www.ncbi.nlm.nih.gov/pubmed/28053111 http://dx.doi.org/10.1098/rsif.2016.0139 |