PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

Notch is a critical regulator of T cell differentiation and is activated through proteolytic cleavage in response to ligand engagement. Using murine myelin-reactive CD4 T cells, we demonstrate that proximal T cell signaling modulates Notch activation by a spatiotemporally constrained mechanism. The...

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Detalles Bibliográficos
Autores principales: Britton, Graham J, Ambler, Rachel, Clark, Danielle J, Hill, Elaine V, Tunbridge, Helen M, McNally, Kerrie E, Burton, Bronwen R, Butterweck, Philomena, Sabatos-Peyton, Catherine, Hampton-O’Neil, Lea A, Verkade, Paul, Wülfing, Christoph, Wraith, David Cameron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310840/
https://www.ncbi.nlm.nih.gov/pubmed/28112644
http://dx.doi.org/10.7554/eLife.20003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310840/
https://www.ncbi.nlm.nih.gov/pubmed/28112644
http://dx.doi.org/10.7554/eLife.20003

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