Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors

Inhibition of bromodomain and extraterminal motif (BET) proteins such as BRD4 bears great promise for cancer treatment and its efficacy has been frequently attributed to Myc downregulation. Here, we use B-cell tumors as a model to address the mechanism of action of JQ1, a widely used BET inhibitor....

Descripción completa

Detalles Bibliográficos
Autores principales: Donato, E, Croci, O, Sabò, A, Muller, H, Morelli, M J, Pelizzola, M, Campaner, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310924/
https://www.ncbi.nlm.nih.gov/pubmed/27443262
http://dx.doi.org/10.1038/leu.2016.182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310924/
https://www.ncbi.nlm.nih.gov/pubmed/27443262
http://dx.doi.org/10.1038/leu.2016.182

Ejemplares similares