Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation

AIM: To clarify the mechanisms involved in the critical endoplasmic reticulum (ER) stress initiating unfolded protein response pathway modified by melatonin. METHODS: Hepatoma cells, HepG2, were cultured in vitro. Flow cytometry and TUNEL assay were used to measure HepG2 cell apoptosis. Western blot...

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Detalles Bibliográficos
Autores principales: Bu, Li-Jia, Yu, Han-Qing, Fan, Lu-Lu, Li, Xiao-Qiu, Wang, Fang, Liu, Jia-Tao, Zhong, Fei, Zhang, Cong-Jun, Wei, Wei, Wang, Hua, Sun, Guo-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311108/
https://www.ncbi.nlm.nih.gov/pubmed/28246472
http://dx.doi.org/10.3748/wjg.v23.i6.986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311108/
https://www.ncbi.nlm.nih.gov/pubmed/28246472
http://dx.doi.org/10.3748/wjg.v23.i6.986

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