BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis

Non-alcoholic steatohepatitis (NASH) is a highly prevalent chronic liver disease. Here, we have investigated whether BAR502, a non-bile acid, steroidal dual ligand for FXR and GPBAR1, reverses steato-hepatitis in mice fed a high fat diet (HFD) and fructose. After 9 week, mice on HFD gained ≈30% of b...

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Detalles Bibliográficos
Autores principales: Carino, Adriana, Cipriani, Sabrina, Marchianò, Silvia, Biagioli, Michele, Santorelli, Chiara, Donini, Annibale, Zampella, Angela, Monti, Maria Chiara, Fiorucci, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311892/
https://www.ncbi.nlm.nih.gov/pubmed/28202906
http://dx.doi.org/10.1038/srep42801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5311892/
https://www.ncbi.nlm.nih.gov/pubmed/28202906
http://dx.doi.org/10.1038/srep42801

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