Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1

The clinical importance of anterior foregut endoderm (AFE) derivatives, such as thyrocytes, has led to intense research efforts for their derivation through directed differentiation of pluripotent stem cells (PSCs). Here, we identify transient overexpression of the transcription factor (TF) NKX2-1 a...

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Detalles Bibliográficos
Autores principales: Dame, Keri, Cincotta, Steven, Lang, Alex H., Sanghrajka, Reeti M., Zhang, Liye, Choi, Jinyoung, Kwok, Letty, Wilson, Talitha, Kańduła, Maciej M., Monti, Stefano, Hollenberg, Anthony N., Mehta, Pankaj, Kotton, Darrell N., Ikonomou, Laertis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312259/
https://www.ncbi.nlm.nih.gov/pubmed/28162994
http://dx.doi.org/10.1016/j.stemcr.2016.12.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312259/
https://www.ncbi.nlm.nih.gov/pubmed/28162994
http://dx.doi.org/10.1016/j.stemcr.2016.12.024

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