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Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors

Zbtb1 is a transcription factor that prevents DNA damage and p53-mediated apoptosis in replicating immune progenitors, affecting lymphoid as well as myeloid development when hematopoietic progenitors are in competition in mixed bone marrow chimeras. However, Zbtb1-deficient mice do not have an appar...

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Detalles Bibliográficos
Autores principales: Zhang, Xianyu, Lu, Ying, Cao, Xin, Zhen, Tao, Kovalovsky, Damian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312274/
https://www.ncbi.nlm.nih.gov/pubmed/27542215
http://dx.doi.org/10.18632/oncotarget.11356