Xanthine oxidoreductase is required for genotoxic stress-induced NKG2D ligand expression and gemcitabine-mediated antitumor activity

MICA/B (the major histocompatibility antigen-related chain A and B) and Rae I are stress-inducible ligands for the immune-receptor NKG2D. Mechanisms by which genotoxic stress and DNA damage induce the expression of NKG2D ligands remain incompletely understood. Here, we report that inhibition of xant...

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Detalles Bibliográficos
Autores principales: Xu, Xiulong, Rao, Geetha, Li, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312307/
https://www.ncbi.nlm.nih.gov/pubmed/27494876
http://dx.doi.org/10.18632/oncotarget.11042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312307/
https://www.ncbi.nlm.nih.gov/pubmed/27494876
http://dx.doi.org/10.18632/oncotarget.11042

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