Cargando…
FOXM1 confers resistance to gefitinib in lung adenocarcinoma via a MET/AKT-dependent positive feedback loop
Gefitinib resistance remains a major problem in the treatment of lung adenocarcinoma. However, the molecular mechanisms of gefitinib resistance are not fully understood. In this study, we characterized the critical role of transcription factor Forkhead box protein M1 (FOXM1) in gefitinib resistance...
Autores principales: | Wang, Yu, Zhang, Weiwei, Wen, Li, Yang, Huiling, Wen, Mingling, Yun, Yuyu, Zhao, Lisheng, Zhu, Xiaofei, Tian, Li, Luo, Erping, Li, Yu, Liu, Wenchao, Wen, Ning |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312309/ https://www.ncbi.nlm.nih.gov/pubmed/27494877 http://dx.doi.org/10.18632/oncotarget.11043 |
Ejemplares similares
-
FoxM1 promotes epithelial–mesenchymal transition, invasion, and migration of tongue squamous cell carcinoma cells through a c-Met/AKT-dependent positive feedback loop
por: Yang, Huiling, et al.
Publicado: (2018) -
FOXM1 promotes reprogramming of glucose metabolism in epithelial ovarian cancer cells via activation of GLUT1 and HK2 transcription
por: Wang, Yu, et al.
Publicado: (2016) -
HGF/Met and FOXM1 Form a Positive Feedback Loop and Render Pancreatic Cancer Cells Resistance to Met Inhibition and Aggressive Phenotypes
por: Cui, Jiujie, et al.
Publicado: (2016) -
FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway
por: Yu, Guanzhen, et al.
Publicado: (2015) -
Licochalcone A Promotes the Ubiquitination of c-Met to Abrogate Gefitinib Resistance
por: Han, Shuangze, et al.
Publicado: (2022)