Bortezomib-induced heat shock response protects multiple myeloma cells and is activated by heat shock factor 1 serine 326 phosphorylation

Proteasome inhibitors such as bortezomib are highly active in multiple myeloma by affecting signaling cascades and leading to a toxic buildup of misfolded proteins. Bortezomib-treated cells activate the cytoprotective heat shock response (HSR), including upregulation of heat shock proteins (HSPs). H...

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Detalles Bibliográficos
Autores principales: Shah, Shardule P., Nooka, Ajay K., Jaye, David L., Bahlis, Nizar J., Lonial, Sagar, Boise, Lawrence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312344/
https://www.ncbi.nlm.nih.gov/pubmed/27487129
http://dx.doi.org/10.18632/oncotarget.10847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312344/
https://www.ncbi.nlm.nih.gov/pubmed/27487129
http://dx.doi.org/10.18632/oncotarget.10847

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