Sensitivity to PRIMA-1(MET) is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status

Alterations of the TP53 tumor suppressor gene occur in ~30% of primary glioblastoma (GBM) with a high frequency of missense mutations associated with the acquisition of oncogenic “gain-of-function” (GOF) mutant (mut)p53 activities. PRIMA-1(MET)/APR-246, emerged as a promising compound to rescue wild...

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Detalles Bibliográficos
Autores principales: Patyka, Mariia, Sharifi, Zeinab, Petrecca, Kevin, Mansure, Jose, Jean-Claude, Bertrand, Sabri, Siham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312382/
https://www.ncbi.nlm.nih.gov/pubmed/27533246
http://dx.doi.org/10.18632/oncotarget.11197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312382/
https://www.ncbi.nlm.nih.gov/pubmed/27533246
http://dx.doi.org/10.18632/oncotarget.11197

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