An oncolytic adenovirus that expresses the HAb18 and interleukin 24 genes exhibits enhanced antitumor activity in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is characterized by alterations in multiple genes. High expression of CD147 on the surface of HCC cells promotes proliferation. The monoclonal antibody HAb18 recognizes CD147. We constructed an oncolytic adenoviral vector to express HAb18 (ZD55-HAb18) in HCC cells. Int...

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Detalles Bibliográficos
Autores principales: Yuan, Sujing, Fang, Xianlong, Xu, Yanni, Ni, Aimin, Liu, Xin-Yuan, Chu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312398/
https://www.ncbi.nlm.nih.gov/pubmed/27528029
http://dx.doi.org/10.18632/oncotarget.11134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312398/
https://www.ncbi.nlm.nih.gov/pubmed/27528029
http://dx.doi.org/10.18632/oncotarget.11134

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