USP9X destabilizes pVHL and promotes cell proliferation

Numerous mutations of the Von Hippel-Lindau (VHL) gene have been reported to cause dysfunction of VHL protein (pVHL) and lead to processes related to tumor progression. pVHL acts as an E3 ligase and degrades downstream targets, such as hypoxia-inducible transcription factor (HIF) which is essential...

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Detalles Bibliográficos
Autores principales: Zhang, Cong, Peng, Zuohan, Zhu, Minglu, Wang, Penglong, Du, Xiao, Li, Xiang, Liu, Yu, Jin, Yan, McNutt, Michael A., Yin, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312400/
https://www.ncbi.nlm.nih.gov/pubmed/27517496
http://dx.doi.org/10.18632/oncotarget.11139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312400/
https://www.ncbi.nlm.nih.gov/pubmed/27517496
http://dx.doi.org/10.18632/oncotarget.11139

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