Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells

Missense mutation of tumor suppressor p53, which exhibits oncogenic gain-of-function (GOF), not only promotes tumor progression, but also diminishes therapeutic efficacies of cancer treatments. However, it remains unclear how a p53 missense mutant contributes to induced pluripotency of cancer stem c...

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Detalles Bibliográficos
Autores principales: Hosain, Salman B., Khiste, Sachin K., Uddin, Mohammad B., Vorubindi, Vindya, Ingram, Catherine, Zhang, Sifang, Hill, Ronald A., Gu, Xin, Liu, Yong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312403/
https://www.ncbi.nlm.nih.gov/pubmed/27517620
http://dx.doi.org/10.18632/oncotarget.11169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312403/
https://www.ncbi.nlm.nih.gov/pubmed/27517620
http://dx.doi.org/10.18632/oncotarget.11169

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