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The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation
BACKGROUND: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA. This activates DNA damage response (DDR) signaling including induction of e...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312431/ https://www.ncbi.nlm.nih.gov/pubmed/28202068 http://dx.doi.org/10.1186/s12985-017-0707-7 |