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The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation

BACKGROUND: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA. This activates DNA damage response (DDR) signaling including induction of e...

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Detalles Bibliográficos
Autores principales:	White, Martyn K., Bellizzi, Anna, Ibba, Gabriele, Pietropaolo, Valeria, Palamara, Anna T., Wollebo, Hassen S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312431/ https://www.ncbi.nlm.nih.gov/pubmed/28202068 http://dx.doi.org/10.1186/s12985-017-0707-7

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