A Novel PEGylation Method for Improving the Pharmacokinetic Properties of Anti-Interleukin-17A RNA Aptamers

The obstacles to the development of therapeutic aptamers for systemic inflammatory diseases, such as nuclease degradation and renal clearance, have not been fully overcome. Here, we report a novel PEGylation method, sbC-PEGylation, which improves the pharmacokinetic properties of RNA aptamers that a...

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Detalles Bibliográficos
Autores principales: Haruta, Kazuhiko, Otaki, Natsuki, Nagamine, Masakazu, Kayo, Tomoyoshi, Sasaki, Asako, Hiramoto, Shinsuke, Takahashi, Masayuki, Hota, Kuniyoshi, Sato, Hideaki, Yamazaki, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312557/
https://www.ncbi.nlm.nih.gov/pubmed/27827561
http://dx.doi.org/10.1089/nat.2016.0627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312557/
https://www.ncbi.nlm.nih.gov/pubmed/27827561
http://dx.doi.org/10.1089/nat.2016.0627

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