Statistical investigation of simulated fed intestinal media composition on the equilibrium solubility of oral drugs

Gastrointestinal fluid is a complex milieu and it is recognised that gut drug solubility is different to that observed in simple aqueous buffers. Simulated gastrointestinal media have been developed covering fasted and fed states to facilitate in vitro prediction of gut solubility and product dissol...

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Detalles Bibliográficos
Autores principales: Zhou, Zhou, Dunn, Claire, Khadra, Ibrahim, Wilson, Clive G., Halbert, Gavin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312627/
https://www.ncbi.nlm.nih.gov/pubmed/27940083
http://dx.doi.org/10.1016/j.ejps.2016.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312627/
https://www.ncbi.nlm.nih.gov/pubmed/27940083
http://dx.doi.org/10.1016/j.ejps.2016.12.008

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