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Statistical investigation of simulated fed intestinal media composition on the equilibrium solubility of oral drugs
Gastrointestinal fluid is a complex milieu and it is recognised that gut drug solubility is different to that observed in simple aqueous buffers. Simulated gastrointestinal media have been developed covering fasted and fed states to facilitate in vitro prediction of gut solubility and product dissol...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science B.V
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312627/ https://www.ncbi.nlm.nih.gov/pubmed/27940083 http://dx.doi.org/10.1016/j.ejps.2016.12.008 |