A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis

The structural flexibility or ‘breathing’ of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at...

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Detalles Bibliográficos
Autores principales: Goo, Leslie, VanBlargan, Laura A., Dowd, Kimberly A., Diamond, Michael S., Pierson, Theodore C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312798/
https://www.ncbi.nlm.nih.gov/pubmed/28207910
http://dx.doi.org/10.1371/journal.ppat.1006178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312798/
https://www.ncbi.nlm.nih.gov/pubmed/28207910
http://dx.doi.org/10.1371/journal.ppat.1006178

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