Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays

The chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one), or 2HMC, displays antileishmanial, antimalarial, and antioxidant activities. The aim of this study was to investigate the cytotoxic, genotoxic, mutagenic, and protective effects of 2HMC using the Ames mutagenicity test, the mo...

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Detalles Bibliográficos
Autores principales: Lima, Débora Cristina da Silva, do Vale, Camila Regina, Véras, Jefferson Hollanda, Bernardes, Aline, Pérez, Caridad Noda, Chen-Chen, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312962/
https://www.ncbi.nlm.nih.gov/pubmed/28207781
http://dx.doi.org/10.1371/journal.pone.0171224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312962/
https://www.ncbi.nlm.nih.gov/pubmed/28207781
http://dx.doi.org/10.1371/journal.pone.0171224

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