Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new therapeutic approach for intervertebral disc disorders

Inhibition of intervertebral disc (IVD) degeneration, which is often accompanied by painful inflammatory and immunopathological processes, is challenging. Current IVD gene therapeutic approaches are based on adenoviral gene delivery systems, which are limited by immune reactions to their viral prote...

Descripción completa

Detalles Bibliográficos
Autores principales: Shenegelegn Mern, Demissew, Tschugg, Anja, Hartmann, Sebastian, Thomé, Claudius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313142/
https://www.ncbi.nlm.nih.gov/pubmed/28207788
http://dx.doi.org/10.1371/journal.pone.0172181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313142/
https://www.ncbi.nlm.nih.gov/pubmed/28207788
http://dx.doi.org/10.1371/journal.pone.0172181

Ejemplares similares